Posts by Category: Biological Informatics

Peptides Guide

June 30, 2017

Peptides Guide
http://www.peptidesguide.com/

Peptides play significant role in cell signaling and function and can be used as an important tool for research and therapeutic treatments. Here we discuss both the structure and activities of peptides as well as strategies for their synthesis. Both peptides and proteins fall under a category called polypeptide chains. These chains contain two or more amino acids (forming amino acid polymers) that are coupled by a peptide bond. The bond is a special linkage between the nitrogen atom of one amino acid and the carboxyl carbon atom of another. Peptides differ from proteins by amount of amino acid residues the molecule contains. Polymer molecules with ten or fewer amino acid residues are called oligopeptides. Peptides often contain up to fifty amino acid residues, protein are molecules with more than fifty amino acid residues. Peptides are functioning in human body on many ways, such as regulating metabolism (insulin) and mediating pain signals (dynorphin). They also play a role in endocrine signaling and can act as a growth factor. Other organisms have produced peptides as a means for defense, such as fungal production of cyclosporin A used clinically as an immunosuppressant, and cone snail secretion of Ziconotide which is used to treat a pain. Modern medicinal and biochemical research is unthinkable without peptides application because of their selectivity, specificity and potency interaction with the target proteins. Peptides’ large size and surface area allow for more specific docking to the target molecules. Researchers’ interest in developing peptide ligands and probes for studying target receptors’ structures and functions has increased dramatically lately. More recently, peptides have been considered as the desirable candidates for therapeutics. Not only can peptides be made very selelctive, decreasing the risk of side effects, but they rapidly metabolize by proteases and allow short time activity in the body. Peptides’ activity can be lengthened by incorporating modifications, such as non-natural and D-amino acids, cyclization and modifications at the N or C-terminus. Therapeutic peptides also have some advantages compared to their protein counterparts. Biological therapeutics, which are generally proteins, have earned an increasing share of the pharmaceutical marketplace over the past few years. While biologics are often highly safe and effective, they must be produced in bioreactors, which use whole cells. Their purification and structural analysis is often complex and expensive. Further, biologics almost invariable must be injected. Peptides, on the other hand, can often be accessed chemically, and their purification and analysis is much simpler. There is also an increasing number of examples of orally active peptides, which make them more desirable for drug development. Endogenous peptides have also been utilized for research and medical interventions. They can be monitored for diagnostic purposes, such as in the case of C-peptide, which is used to monitor insulin production and to help determine the cause of low blood sugar (hypoglycemia). This will be added to Biological Informatics Subject Tracer™.

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The Cell Image Library™

June 16, 2017

The Cell Image Library™
http://www.cellimagelibrary.org/

The Cell Image Library™ is a freely accessible, easy-to-search, public repository of reviewed and annotated images, videos, and animations of cells from a variety of organisms, showcasing cell architecture, intracellular functionalities, and both normal and abnormal processes. The purpose of this database is to advance research, education, and training, with the ultimate goal of improving human health. This will be added to Biological Informatics Subject Tracer™. This will be added to Healthcare Resources Subject Tracer™.

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Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation

June 13, 2017

Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation
http://www.BiologicalInformatics.info/

I have just updated my Subject Tracer™ Information Blog white paper link dataset compilation titled Biological Informatics 2017 which is now a 36 page paper listing selected resources both new and existing that will help anyone who is attempting to find the latest information about biological informatics that are available over the Internet. It is freely available as a .pdf file (305KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was completely updated including link validation and new links added on May 26, 2017. Other white papers are available by clicking here.

This research is powered by Subject Tracer Bots™ available from the Virtual Private Library™.

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EAGLE-I – Search Top Categories From 100,800 Biomedical Resources

June 06, 2017

EAGLE-I – Search Top Categories From 100,800 Biomedical Resources
https://www.eagle-i.net/

eagle-i is a resource discovery tool built to facilitate translational science research. Groundbreaking biomedical research requires access to cutting edge scientific resources, but those resources are often invisible beyond the laboratories or universities where they were developed. Using eagle-i’s free software, you can collect and share information about your research resources, giving any scientist, anywhere, access to one of the largest collections of information about Core Facilities, iPS cell lines, and other valuable, unique or rare scientific resources in the world. FOR RESEARCHERS: Query multiple institutions, connect with other researchers, share or request resources. FOR INSTITUTIONS: Collect and share information about research resources in a highly organized and accessible way. FOR DEVELOPERS: Get the open source software and search semantically rich data resources of all kinds. This will be added to Biological Informatics Subject Tracer™. This will be added to the tools section of Research Resources Subject Tracer™. This will be added to Entrepreneurial Resources Subject Tracer™. This will be added to Academic and Scholar Search Engines and Sources white paper.

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DIRECT2Experts – Distributed Interoperable Biomedical Research Experts Collaboration Tool

May 02, 2017

DIRECT2Experts – Distributed Interoperable Biomedical Research Experts Collaboration Tool
http://direct2experts.org/

The DIRECT2Experts network, open to all biomedical institutions, is a pilot project facilitated by the Research Networking Working Group of the NIH-supported Clinical & Translational Science Award (CTSA) Consortium. Their goal is to improve biomedical research and leverage our strengths as a community by creating a network that enables easy access to expertise and related resources across institutions regardless of local platforms and tools, and in collaboration with participating institutions to ensure access to approved and verified data. What makes DIRECT2Experts different? a) Rather than searching public databases or asking individual researchers to “sign-up”, DIRECT2Experts works directly with institutions to connect to their existing research networking tools.; b) DIRECT2Experts works across different software products and respects local privacy policies, enabling many institutions to participate; and c) The focus of DIRECT2Experts is to bring more institutions and investigators into the fold, allowing for an assessment of the value provided and challenges of searching a national network. This will be added to Internet Experts Subject Tracer™. This will be added to Biological Informatics Subject Tracer™. This will be added to the tools section of Research Resources Subject Tracer™. This will be added to Entrepreneurial Resources Subject Tracer™.

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EdX: The Extremes of Life: Microbes and their Diversity

April 18, 2017

EdX: The Extremes of Life: Microbes and their Diversity
https://www.edx.org/course/extremes-life-microbes-diversity-kyotoux-003x-0

Kyoto University offers this open EdX course dedicated to microorganisms and their role in our world. More specifically, this course investigates microbes that are able to survive in extreme nvironments and temperatures. As the course introduction explains, “Microorganisms are everywhere, and although some are notorious for their roles in human disease, many play important roles in sustaining our global environment.” In this course, anyone can learn more about microbes via video lectures, course readings, and assignments. These materials are divided into four units: Evolution and  the Diversity of Life; Life in Boiling Water; Diversity of Extremophiles; and Genome Sequences. Intended for anyone with a middle-school level knowledge of science, this course is self-paced but designed to be completed in about four weeks. Auditing The Extremes of Life is free; students also have the the option to earn a certificate if they pay a course fee. This will be added to Biological Informatics Subject Tracer™. Copyright © 2017 Internet Scout Research Group – http://scout.wisc.edu

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Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation

March 29, 2017

Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation
http://www.BiologicalInformatics.info/

I have just updated my Subject Tracer™ Information Blog white paper link dataset compilation titled Biological Informatics 2017 which is now a 36 page paper listing selected resources both new and existing that will help anyone who is attempting to find the latest information about biological informatics that are available over the Internet. It is freely available as a .pdf file (303KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was completely updated including link validation and new links added on March 29, 2017. Other white papers are available by clicking here.

This research is powered by Subject Tracer Bots™ available from the Virtual Private Library™.

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Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation

February 11, 2017

Updated> Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation
http://www.BiologicalInformatics.info/

I have just updated my Subject Tracer™ Information Blog white paper link dataset compilation titled Biological Informatics 2017 which is now a 36 page paper listing selected resources both new and existing that will help anyone who is attempting to find the latest information about biological informatics that are available over the Internet. It is freely available as a .pdf file (305KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was completely updated including link validation and new links added on February 11, 2017. Other white papers are available by clicking here.

This research is powered by Subject Tracer Bots™ available from the Virtual Private Library™.

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Genes

January 07, 2017

Genes
http://www.mdpi.com/journal/genes

Genes, a publication of the Multidisciplinary Digital Publishing Institute (MDPI), is an open-access journal dedicated to issues in genetics and genomics. Genes publishes a diverse array of articles, reviews, and case studies on a regular basis and interested readers can check out all published articles via this website. In one recent article, a group of scholars from the College of Computer and Information Science in Saudi Arabia consider computational intelligence programs and non-coding RNA. In another article, a team from the Max Planck Institute of Psychiatry in Germany investigate the possible role of DNA methylation, “an epigenetic mark with important roles in transcription and the mediation of environmental influences” in the development of schizophrenia. In another recently published study, a transnational team of researchers examine nicotine dependence. Each article features links to related articles for those interested in further research. This will be added to Biological Informatics Subject Tracer™. Copyright © 2016 Internet Scout Research Group – http://scout.wisc.edu

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Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation

November 22, 2016

Biological Informatics 2017 Subject Tracer White Paper Link Dataset Compilation
http://www.BiologicalInformatics.info/

I have just updated my Subject Tracer™ Information Blog white paper link dataset compilation titled Biological Informatics 2017 which is now a 36 page paper listing selected resources both new and existing that will help anyone who is attempting to find the latest information about biological informatics that are available over the Internet. It is freely available as a .pdf file (319KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was completely updated including link validation and new links added on November 22, 2016. Other white papers are available by clicking here.

This research is powered by Subject Tracer Bots™ available from the Virtual Private Library™.

295 views