Internet Annotated Link Dataset Compilation white paper titled “Knowledge Discovery Resources 2017” is now a 31 page research paper listing selected resources both new and existing that will help anyone who is attempting to find the latest information about knowledge discovery available on the Internet. Each source is described along with the URL address than can be accessed. Also included is a comprehensive listing of Knowledge Discovery Resources. It is freely available as a .pdf file (235KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A.. Other white papers are available by clicking here. Updated June 30, 2017
This page contains a representative list of major databases and search engines useful in an academic setting for finding and accessing articles in academic journals, repositories, archives, or other collections of scientific and other articles. This will be added to Academic and Scholar Search Engines and Sources white paper. This will be added to the tools section of Research Resources Subject Tracer™.
Peptides play significant role in cell signaling and function and can be used as an important tool for research and therapeutic treatments. Here we discuss both the structure and activities of peptides as well as strategies for their synthesis. Both peptides and proteins fall under a category called polypeptide chains. These chains contain two or more amino acids (forming amino acid polymers) that are coupled by a peptide bond. The bond is a special linkage between the nitrogen atom of one amino acid and the carboxyl carbon atom of another. Peptides differ from proteins by amount of amino acid residues the molecule contains. Polymer molecules with ten or fewer amino acid residues are called oligopeptides. Peptides often contain up to fifty amino acid residues, protein are molecules with more than fifty amino acid residues. Peptides are functioning in human body on many ways, such as regulating metabolism (insulin) and mediating pain signals (dynorphin). They also play a role in endocrine signaling and can act as a growth factor. Other organisms have produced peptides as a means for defense, such as fungal production of cyclosporin A used clinically as an immunosuppressant, and cone snail secretion of Ziconotide which is used to treat a pain. Modern medicinal and biochemical research is unthinkable without peptides application because of their selectivity, specificity and potency interaction with the target proteins. Peptides’ large size and surface area allow for more specific docking to the target molecules. Researchers’ interest in developing peptide ligands and probes for studying target receptors’ structures and functions has increased dramatically lately. More recently, peptides have been considered as the desirable candidates for therapeutics. Not only can peptides be made very selelctive, decreasing the risk of side effects, but they rapidly metabolize by proteases and allow short time activity in the body. Peptides’ activity can be lengthened by incorporating modifications, such as non-natural and D-amino acids, cyclization and modifications at the N or C-terminus. Therapeutic peptides also have some advantages compared to their protein counterparts. Biological therapeutics, which are generally proteins, have earned an increasing share of the pharmaceutical marketplace over the past few years. While biologics are often highly safe and effective, they must be produced in bioreactors, which use whole cells. Their purification and structural analysis is often complex and expensive. Further, biologics almost invariable must be injected. Peptides, on the other hand, can often be accessed chemically, and their purification and analysis is much simpler. There is also an increasing number of examples of orally active peptides, which make them more desirable for drug development. Endogenous peptides have also been utilized for research and medical interventions. They can be monitored for diagnostic purposes, such as in the case of C-peptide, which is used to monitor insulin production and to help determine the cause of low blood sugar (hypoglycemia). This will be added to Biological Informatics Subject Tracer™.
Internet Annotated Link Dataset Compilation white paper titled “Business Intelligence Online Resources 2017” is now a 85 page research paper listing selected resources both new and existing for online business intelligence. Each source is described along with the URL address than can be accessed. Also a comprehensive Business Intelligence Link Dataset Compilation is included! It is freely available as a .pdf file (572KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was completely updated with all links validated and new links added on June 29, 2017. Other white papers are available by clicking here.
Research white paper titled “Current Awareness Discovery Tools on the Internet 2017” is a 25 page research paper listing many resources both new and existing that will help anyone who is attempting to find information and knowledge research about current awareness discovery tools available on the Internet. It is freely available as a .pdf file (579KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A. It was updated on June 28, 2017. Other white papers are available by clicking here.
This program will be featuring my just updated International Trade Resources 2017. We will be highlighting the latest and greatest resources and sources for International Trade covering search engines, subject directories, articles, guides and tracers….literally everything on the Internet covering INTERNATIONAL TRADE!! We will also discussing my latest freely available Awareness Watch Newsletter V15N6 June 2017 featuring World Wide Web Reference on the Internet 2017 as well as my freely available June 2017 Zillman Column highlighting New Economy Resources 2017. You may call in to ask your questions at (718)508-9839. The show is live and thirty minutes in length starting at 2:00pm EDST on Wednesday, June 28, 2017 and then archived for easy review and access. Listen, Call and Enjoy!!
Internet MiniGuide Annotated Link Dataset Compilation white paper titled “Online Social Networking 2017” is now a 40 page research paper listing many resources both new and existing that will help anyone who is attempting to find information and knowledge research about online social networks available on the Internet. It is freely available as a .pdf file (306KB) at the above link from the Virtual Private Library™ and authored by Marcus P. Zillman, M.S., A.M.H.A.. [Completely updated including all links validated and new links added on June 27, 2017]. Other white papers are available by clicking here.
